STUDY REVEALS over 8100 genes affected by hyperbaric oxygen, and it is the pressure that makes all the difference.

Hyperbaric oxygen therapy has been traditionally used for growth, repair, tissue regeneration, and overall recovery. The mechanisms by which these positive effects occur are continuously being explored and our understanding of these effects are growing vastly, and much of these benefits have been shown to occur through the regulation of gene expression in various tissues inside the body. People often wonder why we cannot just breathe pure oxygen and get the same benefits that are achieved through hyperbaric delivery. This study should put those questions at rest and clearly shows the main relevant factor in HBOT is PRESSURE and not the 100% Oxygen. Note, both are considered to be the 2 key variables in dosing hyperbaric oxygen therapy. In this case, the research clearly pointed that the pressure was far more important and just breathing 100% oxygen did not have the physiological benefits that occurred when pressurized oxygen was added. More importantly, researchers in this study observed that pressurized oxygen caused an effect on over 8 thousand genes observed, within a 24 hour period of time following HBOT! <view study>

Hyperbaric Oxygen Therapy Enhances Antioxidant Status Promoting Healthy Aging

Some people still think that HBOT can be harmful by causing excessive oxidative and free radical disease. This study should finally put this controversy at rest. One of the main mechanisms of action in providing HBOT is the body’s compensation and ability to increase its Natural antioxidant defences. In return, the body is more geared at handling our current influx of stressors, including dietary and environmental chemicals. All studies have demonstrated an increase in anti-oxidant protection following HBOT and this study showed the genetic changes in antioxidant levels following HBOT. Here, the gene expressions were increased and thus a considerable elevation in our antioxidant defences. Understanding the role of free radical damage its positive correlation with accelerated aging and chronic disease states, preventative HBOT may hold a key in promoting healthy aging <view study>

Hyperbaric oxygen therapy for traumatic brain injury

This study reviews the effectiveness for applying HBOT for TBI, and makes a strong argument for both the early application, and also for delayed treatments, with the common variable being multiple sessions at low atmospheric pressure. This dosage would reduce intracranial pressure, improve mortality, as well as promote neurobehavioral recovery <view study>

Hyperbaric oxygen therapy protects the body

Free radical, oxidative stress, and inflammation are all common markers that are exhibited during many, if not all, pathologies and the hallmark of many chronic disease states. Hyperbaric oxygen therapy has been traditionally used for reducing the damaging effects of radiation therapy (RT). Since RT has been shown to cause excessive oxidative stress and inflammation, researchers took note of HBOT’s potential to reverse both of these factors involved in radiation damaged tissue <view study>

Hyperbaric oxygen therapy protects and supports the liver

Another study supporting the protective role of hyperbaric oxygen therapy (HBOT). Significant liver protection was observed following HBOT preconditioning. Moreover, both a reduction of oxidative stress, along with a marked enhancement of total antioxidant protection was observed. This is just one of many studies confirming the strong and powerful antioxidant protection that is produced following the application of hyperbaric oxygen therapy <view study>

Hyperbaric oxygen therapy significantly reverses learning and memory deficits

Learning and memory deficits are quite often send following injuries or degenerative disorders of the brain, but now are increasingly becoming a major concern for our aging population. This study focuses on the benefits of hyperbaric oxygen therapy for both of these groups of individuals, particularly the ones with ‘aging’ brains. These beneficial effects were found to be through a combination of positive findings including a reduction in both brain oxidation and inflammation, while also being able to effectively regulate aging-related gene expression. These combined physiological benefits were able to cause a significant reversal in the learning and memory deficits normally observed in aging <view study>

Hyperbaric oxygen therapy protects the brain & positively impacts Cystain C levels

Cystatin C is a bio marker that is becoming a hot topic in neurology, particularly in its ability to predict new-onset or deteriorating cardiovascular disease. Researchers found that preconditioning the brain with hyperbaric oxygen therapy produces helps to protect the brain (neuroprotection), while positively improving the levels of Cystatin C during injury. They published these findings in the journal of “Stroke” 2017 <view study>

New brain tissue growth occurs from long course of hyperbaric oxygen

Hyperbaric oxygen therapy is widely used as an effective off-label use for stroke victims. Research has found that this therapy not only targets oxygenation of the affected area and reduces inflammation, but also has been shown to promote bone marrow stem cells (BMSCs) to proliferate and mobilize, which essentially becomes an important part of the neurogenic (nervous system growth) effects that have been demonstrated from hyperbaric procedures. Mobilization of these BMSCs to the damaged areas was more improved in long course hyperbaric treatments, suggesting the duration of therapy is crucial for promoting their neurogenic effects.

It is important to also note that emerging stem cell research has clearly demonstrated that BMSCs secrete brain-derived neurotrophic factor (BDNF) and the addition of anti-BDNF neutralizing antibodies to MSC-conditioned medium attenuated its neuroprotective effect <view study>

<p>This study also looked at the release of BDNF and found that a 3-week course of HBOT was able to produce significantly higher levels of BDNF and GDNF, than a shorter 2-day course of HBO. These results indicated that longer and repetitive HBO therapy promoted more neurotrophic factor production, including BDNF and GDNF. <view study>

Hyperbaric Oxygen protects the brain and the heart — a necessity for today’s society

With the growing incidence of strokes and heart attacks, medical disabilities for these, and other age-related conditions, are on the rise. Preconditioning the body and its vital organs may be of critical importance for today’s aging and disease-ridden society.

This new study looked at preconditioning the brain with hyperbaric oxygen therapy and showed that it reduced postoperative cognitive dysfunction. More specifically, they reported, “Hyperbaric oxygen preconditioning has proved to protect vital organs, such as the heart, liver, and brain. … We conclude that hyperbaric oxygen preconditioning is an effective and feasible method to prevent, alleviate, and improve postoperative cognitive dysfunction and that its mechanism of action is very complex, involving the stimulation of endogenous antioxidant and anti-inflammation defense systems.” <view study>

Hyperbaric oxygen therapy helps the damaged brain

This study looked at physiological changes that occurred in the brain with the application of hyperbaric therapy following traumatic brain injury. They noticed an improvement in the blood-brain barrier, a reduction in inflammation and inflammatory proteins, a reduction in both swelling and the size of the damage, and more importantly an improvement in neurological status including motor and cognitive function <view study>

Hyperbaric oxygen therapy: A new look on treating stroke and traumatic brain injury

“This study demonstrated the ability of HBOT preconditioning as a treatment for inflammation in stroke and TBI, and reducing neuronal cell death”

Hyperbaric oxygen increases new blood vessels towards traumatic tissue

Following spinal cord injuries, hyperbaric oxygen therapy (HBOT) has been shown to produce a positive effect on healing, but it still remains unclear of the main mechanisms of action. This study followed spinal cord injuries treated with HBOT and demonstrated that this group had higher and longer expressions of VEGF (Vascular endothelial growth factor), which is responsible for the growth of new blood vessels. This follows many other studies and citations, particularly with non-healing wounds, where HBOT facilitates the body to produce more blood vessels to damaged tissue, for long terms benefits <view study>

Preconditioning the brain with hyperbaric oxygen therapy before stroke/TBI to reduce the damage

Currently, there is a great deal of focus and attention being put on hyperbaric oxygen therapy, due to the promising results seen in clinical research and the potential application that this can have for those individuals who have suffered a stroke or TBI. Now, there is strong evidence supporting the use of hyperbaric oxygen therapy BEFORE brain trauma or injury, by preconditioning the brain with hyperbaric oxygen therapy.

This study shows that HBOT preconditioning stands as a robust prophylactic treatment for sequestration of inflammation inherent in stroke and TBI. Though we can’t predict when the brain will be under traumatic stress (unless it’s a planned surgical procedure), hyperbaric oxygen may become one of the best ways to protect our brain from future injuries. The following groups of individuals would be the ones that would most likely benefit:

• Athletes and contact sports affect the head

• Patients undergoing planned brain surgery

• High-risk stroke patients

• Those who are at risk for neurodegenerative conditions

• Elderly

The future holds bright for the application of hyperbaric oxygen therapy for being part of both the treatment of brain trauma and the prevention of the severity of damage that can subsequently occur <view study>